The preliminary outcomes of platelet-rich fibrin injection on pain perception following insertion of archwire: A randomized controlled clinical study

Objectives: This study aimed to determine the efficacy of platelet-rich fibrin (PRF) injection on orthodontic pain perception during 1 st week alignment and leveling process. Material Methods: The sample included 18 patients (11 females 7 males). were randomly divided into two groups, PRF group (9 patients) control patients). mean age members was 21.9 ± 2.5 20.8 2.4 in group, respectively. Conventional brackets applied for both groups. injected six upper front teeth at a rate 0.6 mm each point before starting primary wire insertion parameters patient evaluated groups process by application Visual Analog Scale (VAS) durations (2 h, 6 day, 2 days, days) all followed up until end Results: can reduce patients, overall ( P < 0.05), with an effect size approx. 53 0.13%. biggest observed h after exposure 0.1) which showed 50% reduction group. No significant effects later times > 0.1). Conclusion: present concludes that be effective alternative decreasing levels; however, its needs leveraged immediately PRF.